The TNFSF12 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to DR3L, TNFSF12, TNFSF12-TNFSF13, and TWEAK. This antibody recognizes Human, Mouse, and Rat antigen. The TNFSF12 Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13